Differences in the cargos and functions of exosomes derived from six cardiac cell types: a systematic review

Stem Cell Research & Therapy

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[1] 0000 0004 0369 153X, grid.24696.3f, Department of Cardiology, Beijing Anzhen Hospital, Beijing Institute of Heart, Lung and Blood Vessel Disease, Capital Medical University, 2 Anzhen Road, 100029, Beijing, People’s Republic of China;0000 0004 0369 153X, grid.24696.3f, Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, 95th Yong An Road, Xuan Wu District, 100050, Beijing, People’s Republic of China;grid.452435.1, Department of Cardiology, The First Affiliated Hospital of Dalian Medical University, 222 Zhongshan Road, 116011, Dalian, People’s Republic of China;

关键词: Exosomes;    MicroRNA;    Cardiovascular disease (CVD);    Cardiac cells;   

DOI  :  10.1186/s13287-019-1297-7

来源: publisher

【 摘 要 】

Exosomes are bilayer membrane vesicles with cargos that contain a variety of surface proteins, markers, lipids, nucleic acids, and noncoding RNAs. Exosomes from different cardiac cells participate in the processes of cell migration, proliferation, apoptosis, hypertrophy, and regeneration, as well as angiogenesis and enhanced cardiac function, which accelerate cardiac repair. In this article, we mainly focused on the exosomes from six main types of cardiac cells, i.e., fibroblasts, cardiomyocytes, endothelial cells, cardiac progenitor cells, adipocytes, and cardiac telocytes. This may be the first article to describe the commonalities and differences in regard to the function and underlying mechanisms of exosomes among six cardiac cell types in cardiovascular disease.

【 授权许可】

CC BY