The updated retrospective questionnaire study of sporadic inclusion body myositis in Japan

Orphanet Journal of Rare Diseases

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[1] 0000 0001 0660 6749, grid.274841.c, Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan;0000 0001 1092 3579, grid.267335.6, Department of Clinical Neuroscience, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan;0000 0001 1167 1801, grid.258333.c, Department of Neurology and Geriatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan;0000 0001 2172 5041, grid.410783.9, Department of Neurology, Kansai Medical University, Osaka, Japan;0000 0001 2248 6943, grid.69566.3a, Department of Neurology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980-8574, Sendai, Japan;0000 0001 2248 6943, grid.69566.3a, Department of Neurology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980-8574, Sendai, Japan;Department of Neurology, National Hospital Organization Iwate National Hospital, Iwate, Japan;0000 0001 2248 6943, grid.69566.3a, Department of Neurology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980-8574, Sendai, Japan;Department of Neurology, Southern Tohoku General Hospital, Iwanuma, Miyagi, Japan;0000 0004 1763 1087, grid.412857.d, Department of Neurology, Wakayama Medical University, Wakayama, Japan;0000 0004 1763 8916, grid.419280.6, Department of Neurology, National Center Hospital, National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan;0000 0004 1763 8916, grid.419280.6, Department of Neuromuscular Research, National Institute of Neuroscience and Department of Genome Medicine Development, Medical Genome Center, National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan;0000 0004 1764 9308, grid.416948.6, Department of Neurology, Osaka City General Hospital, Osaka, Japan;grid.416327.5, Department of Neurology, Sendai-Nishitaga National Hospital, Sendai, Japan;

关键词: Sporadic inclusion body myositis;    Multicenter survey;    Questionnaire;    Aging;    Muscle diseasef;   

DOI  :  10.1186/s13023-019-1122-5

来源: publisher

【 摘 要 】

BackgroundSporadic inclusion body myositis (sIBM) is the most prevalent muscle disease in elderly people, affecting the daily activities. sIBM is progressive with unknown cause and without effective treatment. In 2015, sIBM was classified as an intractable disease by the Japanese government, and the treatment cost was partly covered by the government. This study aimed to examine the changes in the number of patients with sIBM over the last 10 years and to elucidate the cross-sectional profile of Japanese patients with sIBM.MethodsThe number of sIBM patients was estimated through a reply-paid postcard questionnaire for attending physicians. Only patients diagnosed as “definite” or “probable” sIBM by clinical and biopsy sIBM criteria were included in this study (Lancet Neurol 6:620-631, 2007, Neuromuscul Disord 23:1044-1055, 2013). Additionally, a registered self-administered questionnaire was also sent to 106 patients who agreed to reply via their attending physician, between November 2016 and March 2017.ResultsThe number of patients diagnosed with sIBM for each 5-year period was 286 and 384 in 2011 and 2016, respectively. Inability to stand-up, cane-dependent gait, inability to open a plastic bottle, choking on food ingestion, and being wheelchair-bound should be included as sIBM milestones. Eight patients were positive for anti-hepatitis C virus antibody; three of them were administered interferon before sIBM onset. Steroids were administered to 33 patients (31.1%) and intravenous immunoglobulin to 46 patients (43.4%). From 2016 to 2017, total of 70 patients applied for the designated incurable disease medical expenses subsidy program. Although the treatment cost was partly covered by the government, many patients expressed psychological/mental and financial anxieties.ConclusionsWe determined the cross-sectional profile of Japanese patients with sIBM. Continuous support and prospective surveys are warranted.

【 授权许可】

CC BY