Harnessing the secretome of adipose-derived stem cells in the treatment of ischemic heart diseases

Stem Cell Research & Therapy

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[1] 0000 0001 0198 0694, grid.263761.7, Department of Cardiovascular Surgery, The First Affiliated Hospital & Institute for Cardiovascular Science, Soochow University, No.899, Pinghai Road, 215006, Suzhou, China;0000 0004 1762 8363, grid.452666.5, Department of Cardiology, The Second Affiliated Hospital of Soochow University, No.1055, Sanxiang Road, 215004, Suzhou, China;0000 0004 1762 8363, grid.452666.5, Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Soochow University, No.1055, Sanxiang Road, 215004, Suzhou, China;

关键词: Adipose-derived stem cells;    Ischemic heart diseases;    Paracrine effects;    Secretome;    Myocardial repair;    Strategies;   

DOI  :  10.1186/s13287-019-1289-7

来源: publisher

【 摘 要 】

Adipose-derived stem cells (ASCs) are promising therapeutic cells for ischemic heart diseases, due to the ease and efficiency of acquisition, the potential of myocardial lineage differentiation, and the paracrine effects. Recently, many researchers have claimed that the ASC-based myocardial repair is mainly attributed to its paracrine effects, including the anti-apoptosis, pro-angiogenesis, anti-inflammation effects, and the inhibition of fibrosis, rather than the direct differentiation into cardiovascular lineage cells. However, the usage of ASCs comes with the problems of low cardiac retention and survival after transplantation, like other stem cells, which compromises the effectiveness of the therapy. To overcome these drawbacks, researchers have proposed various strategies for improving survival rate and ensuring sustained paracrine secretion. They also investigated the safety and efficacy of phase I and II clinical trials of ASC-based therapy for cardiovascular diseases. In this review, we will discuss the characterization and paracrine effects of ASCs on myocardial repair, followed by the strategies for stimulating the paracrine secretion of ASCs, and finally their clinical usage.

【 授权许可】

CC BY