Clusterization of co-morbidities and multi-morbidities among persons living with HIV: a cross-sectional study

BMC Infectious Diseases

  ^{1    1    1    2    3    3    4    4    5    6    7    8    8    8    9    1,10    1,11} 

[1] 0000 0001 0120 3326, grid.7644.1, Infectious Diseases Clinic, University of Bari, Bari, Italy;0000 0001 2174 1754, grid.7563.7, Infectious Diseases Unit ASST-MONZA, San Gerardo Hospital-University of Milano-Bicocca, Monza, Italy;0000 0001 2200 8888, grid.9841.4, Infectious Diseases Clinic University of Campania “Luigi Vanvitelli”, Neaples, Italy;0000 0004 0493 6789, grid.413175.5, Unit of Infectious Diseases, A. Manzoni Hospital, Lecco, Italy;0000 0004 1756 7871, grid.410345.7, Infectious Diseases, San Martino Hospital Genoa, Genoa, Italy;0000 0004 1757 8749, grid.414818.0, Department of Women, Child and Neonate, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy;0000 0004 1759 6488, grid.415194.c, Infectious Diseases Unit, Santa Maria Annunziata Hospital, Usl centro, Florence, Italy;0000 0004 1760 3158, grid.417287.f, Infectious Diseases Clinic, Department of Medicine 2, Azienda Ospedaliera di Perugia and University of Perugia, Santa Maria Hospital, Perugia, Italy;0000 0004 1760 3158, grid.417287.f, Infectious Diseases Clinic, Department of Medicine 2, Azienda Ospedaliera di Perugia and University of Perugia, Santa Maria Hospital, Perugia, Italy;0000 0004 1757 3630, grid.9027.c, Infectious Diseases Clinic, “Santa Maria” Hospital, University of Perugia, Terni, Italy;Division I of Infectious and Tropical Diseases, ASL Città di Torino, Torino, Italy;Unit of Infectious Diseases, ASST della Valle Olona, Busto Arsizio, VA, Italy;

关键词: HIV;    Co-morbidity;    Multi-morbidity;    Disease-disease interactions;    Clusterization;   

DOI  :  10.1186/s12879-019-4184-z

来源: publisher

【 摘 要 】

BackgroundAmong people living with HIV (PLWH), the prevalence of non-HIV related co-morbidities is increasing. Aim of the present study is to describe co-morbidity and multi-morbidity, their clustering mode and the potential disease-disease interactions in a cohort of Italian HIV patients.MethodsCross-sectional analysis conducted by the Coordinamento Italiano per lo Studio di Allergia e Infezioni da HIV (CISAI) on adult subjects attending HIV-outpatient facilities. Non-HIV co-morbidities included: cardiovascular disease, diabetes mellitus, hypertension, oncologic diseases, osteoporosis, probable case of chronic obstructive pulmonary disease (COPD), hepatitis C virus (HCV) infection, psychiatric illness, kidney disease. Multi-morbidity was defined as the presence of two or more co-morbidities.ResultsOne thousand and eighty-seven patients were enrolled in the study (mean age 47.9 ± 10.8). One hundred-ninety patients (17.5%) had no co-morbidity, whereas 285 (26.2%) had one condition and 612 (56.3%) were multi-morbid. The most recurrent associations were: 1) dyslipidemia + hypertension (237, 21.8%); 2) dyslipidemia + COPD (188, 17.3%); 3) COPD + HCV-Ab+ (141, 12.9%). Multi-morbidity was associated with older age, higher body mass index, current and former smoking, CDC stage C and longer ART duration.ConclusionsMore than 50% of PLHW were multi-morbid and about 30% had three or more concurrent comorbidities. The identification of common patterns of comorbidities address the combined risks of multiple drug and disease-disease interactions.

【 授权许可】

CC BY