Prognostic value of ZEB-1 in solid tumors: a meta-analysis

BMC Cancer

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[1] 0000 0004 1797 9307, grid.256112.3, Department of Gastrointestinal Surgery, First Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, China;Department of Endoscopy Center, Xiamen Branch of Affiliated Zhongshan Hospital of Fudan University, Xiamen, Fujian, China;grid.412625.6, Department of Endoscopy Center, First Affiliated Hospital of Xiamen University, Xiamen, China;grid.412625.6, Department of Gastrointestinal Surgery, Xiamen Cancer Hospital of The First Affiliated Hospital of Xiamen University, 55 Zhen Hai Road, Si Ming District, 361003, Xiamen, Fujian Province, China;grid.412625.6, Department of Gastrointestinal Surgery, Xiamen Cancer Hospital of The First Affiliated Hospital of Xiamen University, 55 Zhen Hai Road, Si Ming District, 361003, Xiamen, Fujian Province, China;0000 0004 1797 9307, grid.256112.3, Department of Gastrointestinal Surgery, First Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, China;grid.452887.4, Department of Breast Surgery, The Third Hospital of Nanchang City, Key Laboratory of Breast Diseases, Nanchang, Jiangxi, China;

关键词: ZEB-1;    Overall survival;    Solid tumor;    Meta-analysis;   

DOI  :  10.1186/s12885-019-5830-y

来源: publisher

【 摘 要 】

BackgroundZinc-finger E-box binding homeobox 1 (ZEB-1) plays crucial roles in epithelial-to-mesenchymal transition during tumor carcinogenesis. Published studies have examined the potential value of ZEB-1 as a biomarker for the prognosis of cancer. Nevertheless, the prognostic significance of ZEB-1 in human solid tumor remains inconclusive. Therefore, we performed the present meta-analysis to evaluate the prognostic value of ZEB-1 in patients with solid tumors.MethodsThe 13 included studies (1616 patients) were exact electronic searched from Web of Science, PubMed and EBSCO until September 2018. Pooled hazard ratios (HR) and the corresponding 95% confidence intervals (CI) for overall survival (OS) were analyzed through random or fixed effects models. Univariate and multivariate analyses were independently performed. Subgroup analyses, heterogeneity and publication bias were investigated to further enhance reliability.ResultsThis research indicated that elevated expression of ZEB-1 significantly predicted worse OS in patients with solid tumors. In the univariate analysis, the pooled HR for OS was 1.66 (95% CI: 1.45–1.90; P < 0.01). Meanwhile, in multivariate analysis, the pooled HR for OS was 2.28 (95% CI: 1.58–3.30; P < 0.01). Begg’s funnel plot and Begg’s test did not show evidence of significant publication bias, both in univariate analysis and multivariate analysis.ConclusionsHigh expression of ZEB-1 was associated with poorer OS, suggesting that ZEB-1 may be a potential biomarker for the prediction of prognosis, and a novel therapeutic target in human solid tumors.

【 授权许可】

CC BY