An improved method of delivering a sclerosing agent for the treatment of malignant pleural effusion

BMC Cancer

  ^{1    1    2    3    3    4    5    6    7} 

[1] 0000 0001 2181 3113, grid.166341.7, Department of Cardiothoracic Surgery, Drexel University College of Medicine, Hahnemann University Hospital, 230 North Broad Street, 19102, Philadelphia, PA, USA;0000 0001 2181 3113, grid.166341.7, Department of Chemical and Biological Engineering, Drexel University, 19129, Philadelphia, PA, USA;0000 0001 2181 3113, grid.166341.7, Department of Pathology, Drexel University College of Medicine, 19129, Philadelphia, PA, USA;0000 0004 0456 6466, grid.412530.1, Program in Molecular Therapeutics, Fox Chase Cancer Center, 19111, Philadelphia, PA, USA;0000 0004 0456 6466, grid.412530.1, Program in Molecular Therapeutics, Fox Chase Cancer Center, 19111, Philadelphia, PA, USA;0000 0001 0675 4725, grid.239578.2, Digestive Disease & Surgery Institute, Cleveland Clinic, 9500 Euclid Avenue, 44195, Cleveland, OH, USA;0000 0004 0456 6466, grid.412530.1, Program in Molecular Therapeutics, Fox Chase Cancer Center, 19111, Philadelphia, PA, USA;0000 0004 0543 9688, grid.77268.3c, Department of Biochemistry, Kazan Federal University, Kazan, Russia;0000 0004 0543 9688, grid.77268.3c, Department of Biochemistry, Kazan Federal University, Kazan, Russia;0000 0004 0456 6466, grid.412530.1, Department of Hematology/Oncology, Fox Chase Cancer Center, 19111, Philadelphia, PA, USA;

关键词: Lung cancer;    Metastatic cancer;    Talc;    Pleurodesis;    Malignant pleural effusion;    Mouse model;    Sclerosing agent;    Thermosensitive hydrogel;   

DOI  :  10.1186/s12885-019-5777-z

来源: publisher

【 摘 要 】

BackgroundMalignant pleural effusion (MPE) is a devastating sequela associated with cancer. Talc pleurodesis is a common treatment strategy for MPE but has been estimated to be unsuccessful in up to 20–50% of patients. Clinical failure of talc pleurodesis is thought to be due to poor dispersion. This monograph reports the development of a foam delivery system designed to more effectively coat the pleural cavity.MethodsC57BL/6 mice were injected with Lewis lung carcinoma (LL/2) cells intrapleurally to induce MPE. The mice then received either normal saline (NS) control, foam control (F), talc slurry (TS, 2 mg/g) or talc foam (TF, 2 mg/g). Airspace volume was evaluated by CT, lungs/pleura were collected, and percent fibrosis was determined.ResultsThe TF group had significantly better survival than the TS group (21 vs 13.5 days, p < 0.0001). The average effusion volume was less in the talc groups compared to the control group (140 vs 628 μL, p < 0.001). TF induced significant lung fibrosis (p < 0.01), similar to TS. On CT, TF significantly (p < 0.05) reduced loss of right lung volume (by 30–40%) compared to the control group. This was not seen with TS (p > 0.05).ConclusionsThis report describes using a novel talc foam delivery system for the treatment of MPE. In the LL/2 model, mice treated with the TF had better survival outcomes and less reduction of lung volume than mice treated with the standard of care TS. These data provide support for translational efforts to move talc foam from animal models into clinical trials.

【 授权许可】

CC BY