European headache federation guideline on the use of monoclonal antibodies acting on the calcitonin gene related peptide or its receptor for migraine prevention

The Journal of Headache and Pain

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[1] 0000 0001 0674 042X, grid.5254.6, Department of Neurology, Danish Headache Center, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark;0000 0001 2155 0800, grid.5216.0, 1st Department of Neurology, National and Kapodistrian University of Athens, Athens, Greece;0000 0001 2218 4662, grid.6363.0, Department of Neurology, Charité Universitätsmedizin Berlin, Berlin, Germany;0000 0004 1757 2611, grid.158820.6, Neuroscience Section, Department of Applied Clinical Sciences and Biotechnology, University of L’Aquila, via Vetoio, 67100, L’Aquila, Italy;0000000089452978, grid.10419.3d, Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands;grid.7841.a, Department of Clinical and Molecular Medicine, Sapienza University, Rome, Italy;

关键词: Migraine;    Chronic migraine;    Prevention;    Erenumab;    Fremanezumab;    Galcazenumab;    Eptinezumab;    Calcitonin gene-related peptide;   

DOI  :  10.1186/s10194-018-0955-y

来源: publisher

【 摘 要 】

Background and aimMonoclonal antibodies acting on the calcitonin gene-related peptide or on its receptor are new drugs to prevent migraine. Four monoclonal antibodies have been developed: one targeting the calcitonin gene-related peptide receptor (erenumab) and three targeting the calcitonin gene-related peptide (eptinezumab, fremanezumab, and galcanezumab). The aim of this document by the European Headache Federation (EHF) is to provide an evidence-based and expert-based guideline on the use of the monoclonal antibodies acting on the calcitonin gene-related peptide for migraine prevention.MethodsThe guideline was developed following the Grading of Recommendation, Assessment, Development, and Evaluation (GRADE) approach. The working group identified relevant questions, performed systematic review and analysis of the literature, assessed the quality of available evidence, and wrote recommendations. Where the GRADE approach was not applicable, expert opinion was provided.ResultsWe found low to high quality of evidence to recommend eptinezumab, erenumab, fremanezumab, and galcanezumab in patients with episodic migraine and medium to high quality of evidence to recommend erenumab, fremanezumab, and galcanezumab in patients with chronic migraine. For several clinical questions, there was not enough evidence to provide recommendations using the GRADE approach and recommendations relied on experts’ opinion.ConclusionMonoclonal antibodies acting on the calcitonin gene-related peptide are new drugs which can be recommended for migraine prevention. Real life data will be useful to improve the use of those drugs in clinical practice.

【 授权许可】

CC BY