Generalizability and reproducibility of functional connectivity in autism

Molecular Autism

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[1] 0000 0001 2167 3675, grid.14003.36, Waisman Center, University of Wisconsin-Madison, 53705, Madison, WI, USA;0000 0001 2167 3675, grid.14003.36, Waisman Center, University of Wisconsin-Madison, 53705, Madison, WI, USA;0000 0001 2167 3675, grid.14003.36, Department of Psychiatry, University of Wisconsin-Madison, 53719, Madison, WI, USA;0000 0001 2167 3675, grid.14003.36, Waisman Center, University of Wisconsin-Madison, 53705, Madison, WI, USA;0000 0001 2167 3675, grid.14003.36, Department of Psychiatry, University of Wisconsin-Madison, 53719, Madison, WI, USA;0000 0001 2167 3675, grid.14003.36, Department of Medical Physics, University of Wisconsin-Madison, 53705, Madison, WI, USA;0000 0001 2193 0096, grid.223827.e, Department of Pediatrics, University of Utah, 84108, Salt Lake City, UT, USA;0000 0001 2167 3675, grid.14003.36, Waisman Center, University of Wisconsin-Madison, 53705, Madison, WI, USA;0000 0001 2193 0096, grid.223827.e, Department of Pediatrics, University of Utah, 84108, Salt Lake City, UT, USA;0000 0001 2193 0096, grid.223827.e, Department of Neurology, University of Utah, 84132, Salt Lake City, UT, USA;0000 0001 2193 0096, grid.223827.e, Department of Radiology and Imaging Sciences, University of Utah, 84108, Salt Lake City, UT, USA;0000 0001 2193 0096, grid.223827.e, Department of Radiology and Imaging Sciences, University of Utah, 84108, Salt Lake City, UT, USA;0000 0001 2193 0096, grid.223827.e, Department of Biomedical Engineering, University of Utah, 84112, Salt Lake City, UT, USA;0000 0001 2193 0096, grid.223827.e, Department of Radiology and Imaging Sciences, University of Utah, 84108, Salt Lake City, UT, USA;0000 0001 2193 0096, grid.223827.e, Department of Pediatrics, University of Utah, 84108, Salt Lake City, UT, USA;0000 0001 2193 0096, grid.223827.e, Department of Radiology and Imaging Sciences, University of Utah, 84108, Salt Lake City, UT, USA;0000 0001 2193 0096, grid.223827.e, Department of Pediatrics, University of Utah, 84108, Salt Lake City, UT, USA;0000 0001 2167 3675, grid.14003.36, Waisman Center, University of Wisconsin-Madison, 53705, Madison, WI, USA;0000 0001 2193 0096, grid.223827.e, Department of Radiology and Imaging Sciences, University of Utah, 84108, Salt Lake City, UT, USA;0000 0001 2193 0096, grid.223827.e, Interdepartmental Program in Neuroscience, University of Utah, 84112, Salt Lake City, UT, USA;0000 0001 2193 0096, grid.223827.e, Department of Radiology and Imaging Sciences, University of Utah, 84108, Salt Lake City, UT, USA;0000 0001 2193 0096, grid.223827.e, Interdepartmental Program in Neuroscience, University of Utah, 84112, Salt Lake City, UT, USA;0000 0001 2193 0096, grid.223827.e, Department of Biomedical Engineering, University of Utah, 84112, Salt Lake City, UT, USA;0000 0004 1936 9115, grid.253294.b, Psychology Department and Neuroscience Center, Brigham Young University, 84604, Provo, UT, USA;000000041936754X, grid.38142.3c, McLean Hospital and Department of Psychiatry, Harvard University, 02478, Cambridge, MA, USA;

关键词: Autism spectrum conditions;    Resting-state;    fMRI;    Functional connectivity MRI;    Replicability;    Reproducibility;   

DOI  :  10.1186/s13229-019-0273-5

来源: publisher

【 摘 要 】

BackgroundAutism is hypothesized to represent a disorder of brain connectivity, yet patterns of atypical functional connectivity show marked heterogeneity across individuals.MethodsWe used a large multi-site dataset comprised of a heterogeneous population of individuals with autism and typically developing individuals to compare a number of resting-state functional connectivity features of autism. These features were also tested in a single site sample that utilized a high-temporal resolution, long-duration resting-state acquisition technique.ResultsNo one method of analysis provided reproducible results across research sites, combined samples, and the high-resolution dataset. Distinct categories of functional connectivity features that differed in autism such as homotopic, default network, salience network, long-range connections, and corticostriatal connectivity, did not align with differences in clinical and behavioral traits in individuals with autism. One method, lag-based functional connectivity, was not correlated to other methods in describing patterns of resting-state functional connectivity and their relationship to autism traits.ConclusionOverall, functional connectivity features predictive of autism demonstrated limited generalizability across sites, with consistent results only for large samples. Different types of functional connectivity features do not consistently predict different symptoms of autism. Rather, specific features that predict autism symptoms are distributed across feature types.

【 授权许可】

CC BY