Genomic Analysis To Identify Signatures of Artificial Selection and Loci Associated with Important Economic Traits in Duroc Pigs

G3: Genes, Genomes, Genetics

article

Yunlong Ma¹  Saixian Zhang¹  Kaili Zhang¹  Chengchi Fang¹  Shengsong Xie¹  Xiaoyong Du¹  Xinyun Li¹  Debin Ni¹  Shuhong Zhao¹ 

[1] Key Laboratory of Agricultural Animal Genetics, Breeding, and Reproduction of the Ministry of Education & Key Laboratory of Swine Genetics and Breeding of the Ministry of Agriculture, Huazhong Agricultural University, Wuhan 430070, P. R. China

关键词: Duroc pig;    Artificial selection signatures;    Genome-wide association study;    Economic traits;   

DOI  :  10.1534/g3.118.200665

学科分类：社会科学、人文和艺术（综合）

来源: Genetics Society of America

【 摘 要 】

Identifying genetic basis of domestication and improvement in livestock contributes to our understanding of the role of artificial selection in shaping the genome. Here we used whole-genome sequencing and the genotyping by sequencing approach to detect artificial selection signatures and identify the associated SNPs of two economic traits in Duroc pigs. A total of 38 candidate selection regions were detected by combining the fixation index and the Composite Likelihood Ratio methods. Further genome-wide association study revealed seven associated SNPs that were related with intramuscular fat content and feed conversion ratio traits, respectively. Enrichment analysis suggested that the artificial selection regions harbored genes, such as MSTN , SOD2 , MC5R and CD83 , which are responsible for economic traits including lean muscle mass, fertility and immunization. Overall, this study found a series of candidate genes putatively associated with the breeding improvement of Duroc pigs and the polygenic basis of adaptive evolution, which can provide important references and fundamental information for future breeding programs.

【 授权许可】

CC BY|CC BY-NC