Sex Differences in Recombination in Sticklebacks

G3: Genes, Genomes, Genetics

article

Jason M. Sardell¹  Changde Cheng¹  Andrius J. Dagilis¹  Asano Ishikawa²  Jun Kitano²  Catherine L. Peichel³  Mark Kirkpatrick¹ 

[1] Department of Integrative Biology, University of Texas at Austin, Texas 78712;Department of Population Genetics, National Institute of Genetics, Mishima, Shizuoka 411-8540, Japan;Institute of Ecology and Evolution, University of Bern, 3012, Switzerland

关键词: recombination;    heterochiasmy;    genomic differentiation;    chromosome center biased differentiation;    sex chromosomes;   

DOI  :  10.1534/g3.118.200166

学科分类：社会科学、人文和艺术（综合）

来源: Genetics Society of America

【 摘 要 】

Recombination often differs markedly between males and females. Here we present the first analysis of sex-specific recombination in Gasterosteus sticklebacks. Using whole-genome sequencing of 15 crosses between G. aculeatus and G. nipponicus , we localized 698 crossovers with a median resolution of 2.3 kb. We also used a bioinformatic approach to infer historical sex-averaged recombination patterns for both species. Recombination is greater in females than males on all chromosomes, and overall map length is 1.64 times longer in females. The locations of crossovers differ strikingly between sexes. Crossovers cluster toward chromosome ends in males, but are distributed more evenly across chromosomes in females. Suppression of recombination near the centromeres in males causes crossovers to cluster at the ends of long arms in acrocentric chromosomes, and greatly reduces crossing over on short arms. The effect of centromeres on recombination is much weaker in females. Genomic differentiation between G. aculeatus and G. nipponicus is strongly correlated with recombination rate, and patterns of differentiation along chromosomes are strongly influenced by male-specific telomere and centromere effects. We found no evidence for fine-scale correlations between recombination and local gene content in either sex. We discuss hypotheses for the origin of sexual dimorphism in recombination and its consequences for sexually antagonistic selection and sex chromosome evolution.

【 授权许可】

CC BY|CC BY-NC