Roles of neutrophils in cancer growth and progression

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

article

Maria Rosaria Galdiero¹  Gilda Varricchi¹  Stefania Loffredo¹  Alberto Mantovani⁴  Gianni Marone¹ 

[1] Department of Translational Medical Sciences (DiSMeT), University of Naples Federico II, Naples, Italy;Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, Naples, Italy;WAO Center of Excellence, University of Naples Federico II, Naples, Italy;Humanitas Clinical and Research Center, Rozzano, Milan, Italy;Department of Biomedical Sciences, Humanitas University, Milan, Italy;Institute of Experimental Endocrinology and Oncology “Gaetano Salvatore” (IEOS), National Research Council (CNR), Naples, Italy

关键词: cancer‐related inflammation;    cancer immunotherapy;    predictive biomarker;    prognostic factor;    tumor‐associated neutrophils;   

DOI  :  10.1002/JLB.3MR0717-292R

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Chronic inflammation is a well‐known tumor‐enabling capacity, which allows nascent tumors to acquire all the hallmark capabilities, including the escape from immunosurveillance. Soluble and cellular inflammatory mediators constitute the complex network of the tumor microenvironment, in which tumors grow and with which constantly interact. Myeloid cells (e.g., tumor associated macrophages) are pivotal players of the tumor microenvironment and are characterized by plasticity, which consists of the ability to acquire distinct phenotypes in response to the microenvironment in which they reside. Neutrophils are emerging as important players of tumor microenvironment, given their heterogeneity and plasticity. Increasing evidence suggests a dual role for neutrophils in modulating tumor behavior and highlights the need for a reassessment of neutrophil functions in cancer initiation and progression.

【 授权许可】

CC BY