Role of chemokines in ectopic lymphoid structures formation in autoimmunity and cancer

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

article

Alessandra Nerviani¹  Costantino Pitzalis¹ 

[1] Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry Queen Mary University of London London UK

关键词: chemokines;    ectopic lymphoid structures;    rheumatoid arthritis;    synovium;   

DOI  :  10.1002/JLB.3MR0218-062R

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Ectopic (or tertiary) lymphoid structures (ELS) are organized aggregates of lymphocytes resembling secondary lymphoid organs and developing in chronically inflamed nonlymphoid tissues during persistent infections, graft rejection, autoimmune conditions, and cancer. In this review, we will first depict the mechanisms regulating ELS generation, focusing on the role played by lymphoid chemokines. We will then characterize ELS forming in target organs during autoimmune conditions, here exemplified by rheumatoid arthritis, and cancer, highlighting the relevance of the tissue‐specific factors. Finally, we will discuss the clinical significance of ELS and the therapeutic potential of their inhibition and/or enhancement depending on the disease considered.

【 授权许可】

CC BY