Diversity and environmental adaptation of phagocytic cell metabolism

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

article

Luke C. Davies¹  Christopher M. Rice¹  Daniel W. McVicar¹  Jonathan M. Weiss¹ 

[1] Cancer & Inflammation Program National Cancer Institute Frederick Maryland USA;Division of Infection & Immunity School of Medicine Cardiff University Heath Park UK

关键词: glycolysis;    niche diversity;    oxidative phosphorylation;    phagocyte metabolism;   

DOI  :  10.1002/JLB.4RI0518-195R

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Phagocytes are cells of the immune system that play important roles in phagocytosis, respiratory burst and degranulation—key components of innate immunity and response to infection. This diverse group of cells includes monocytes, macrophages, dendritic cells, neutrophils, eosinophils, and basophils—heterogeneous cell populations possessing cell and tissue‐specific functions of which cellular metabolism comprises a critical underpinning. Core functions of phagocytic cells are diverse and sensitive to alterations in environmental‐ and tissue‐specific nutrients and growth factors. As phagocytic cells adapt to these extracellular cues, cellular processes are altered and may contribute to pathogenesis. The considerable degree of functional heterogeneity among monocyte, neutrophil, and other phagocytic cell populations necessitates diverse metabolism. As we review our current understanding of metabolism in phagocytic cells, gaps are focused on to highlight the need for additional studies that hopefully enable improved cell‐based strategies for counteracting cancer and other diseases.

【 授权许可】

CC BY