Type I IFNs in the female reproductive tract: The first line of defense in an ever‐changing battleground

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

article

Helen E. Cumming¹  Nollaig M. Bourke² 

[1] Centre for Innate Immunity and Infectious Diseases Hudson Institute of Medical Research Monash University Clayton VIC Australia;Department of Medical Gerontology Trinity Translational Medicine Institute Trinity College Dublin, Dublin Ireland

关键词: Chlamydia;    female reproductive tract;    HIV;    hormonal regulation;    mucosal immunity;    Type I IFNs;    Zika;   

DOI  :  10.1002/JLB.MR0318-122RR

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

The primary function of the female reproductive tract (FRT) is to enable successful reproduction, yet the biologic mechanisms required to accomplish this, which include fluctuating sex hormones and tolerance of semen and a semi‐allogeneic fetus, can leave this unique mucosal environment susceptible to pathogenic challenge. Consequently, the FRT has evolved specialized innate and adaptive immune responses tailored to protecting itself from infection without compromising reproductive success. A family of innate immune cytokines that has emerged as important regulators of these immune responses is the type I IFNs. Type I IFNs are typically rapidly produced in response to pathogenic stimulation and are capable of sculpting pleotropic biologic effects, including immunomodulation, antiproliferative effects, and inducing antiviral and bactericidal molecules. Here, we review what is currently known about type I IFN‐mediated immunity in the FRT in human, primate, and murine models and explore their importance with respect to three highly relevant FRT infections: HIV, Zika, and Chlamydia.

【 授权许可】

CC BY