Lymphocyte mechanotransduction: The regulatory role of cytoskeletal dynamics in signaling cascades and effector functions

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

article

Aviad BenShmuel¹  Noah Joseph¹  Batel Sabag¹  Mira BardaSaad¹ 

[1] Laboratory of Molecular and Applied Immunology Bar‐Ilan University The Mina and Everard Goodman Faculty of Life Sciences Ramat‐Gan Israel

关键词: actin;    cytoskeleton;    mechanosensing;    NK cells;    signaling;   

DOI  :  10.1002/JLB.MR0718-267R

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

The process of mechanotransduction, that is, conversion of physical forces into biochemical signaling cascades, has attracted interest as a potential mechanism for regulating immune cell activation. The cytoskeleton serves a critical role in a variety of lymphocyte functions, from cellular activation, proliferation, adhesion, and migration, to creation of stable immune synapses, and execution of functions such as directed cytotoxicity. Though traditionally considered a scaffold that enables formation of signaling complexes that maintain stable immune synapses, the cytoskeleton was additionally shown to play a dynamic role in lymphocyte signaling cascades by sensing physical cues such as substrate rigidity, and transducing these mechanical features into chemical signals that ultimately influence lymphocyte effector functions. It is thus becoming clear that cytoskeletal dynamics are essential for the lymphocyte response, beyond the role of the cytoskeleton as a stationary framework. Here, we describe the transduction of extracellular forces to activate signaling pathways and effector functions mediated through the cytoskeleton in lymphocytes. We also highlight recent discoveries of cytoskeleton‐mediated mechanotransduction on intracellular signaling pathways in NK cells.

【 授权许可】

CC BY