A case of DAPSONE INDUCED METHEMOGLOBINEMIA

Southern Med Review

article

Najia Mahmood¹  Mutti Ullah Khan²  Ihtisham U. L. Haq²  Farhat Afshan Jelani²  Aayesha Tariq³ 

[1] FCPS Medicine, Holy Family Hospital, Rawalpindi Medical University and Allied Hospitals, Rawalpindi, Pakistan;FCPS Anesthesia, Combined Military Hospital, Sargodha, Pakistan;Pakistan Atomic Energy Commission General Hospital, Islamabad, Pakistan

关键词: Cyanosis;    Methemoglobinemia;    Oxidizing agent;    Tissue hypoxia;   

DOI  :  10.1186/s40545-019-0185-y

学科分类：药理学

来源: BioMed Central

【 摘 要 】

Methemoglobinemia (MetHb) being a rare cause of cyanosis is generally not considered in its differential diagnosis. Methemoglobinemia is an abnormal Hb produced physiologically by auto-oxidation. If this process of auto oxidation is impaired either due to genetic defect or due to exogenous drugs/ toxins, its level starts rising. Once it is > 3%, tissue hypoxia ensues. Here is a case of dapsone induced MetHb and is reported in a young girl with central cyanosis, and was treated successfully with methylene blue. Methemoglobinemia should be considered in differential diagnoses of cyanosed patient with normal ABGs, PaO2 and cardio-respiratory status. If left untreated, the disease can be fatal.

【 授权许可】

Unknown