Effect of pramipexole alginate nanodispersion (PAND) on the transgenic Drosophila expressing human alpha synuclein in the brain

Journal of Applied Biomedicine

关键词: Pramipexole;    Parkinson’s disease;    Oxidative stress;    Drosophila melanogaster;    Nanocomposite;   

DOI  :  10.1016/j.jab.2017.11.002

学科分类：医学（综合）

来源: Elsevier

【 摘 要 】

In the present study the effect of pramipexole alginate nanodispersion (PAND) was studied on the transgenic Drosophila exhibiting the PD symptoms. The PD flies were allowed to feed on the diet having PAND at final concentration of 1, 2 and 3 μM. A dose dependent significant delay in the loss of climbing ability and improvement in the activity was observed in PD flies. A dose dependent significant change in the oxidative stress markers and dopamine content was also observed in the PD flies exposed to various doses PAND. The improvement in the PD symptoms was more in PD flies exposed to PAND compared to PD flies exposed to pramipexole alone.

【 授权许可】

Unknown