Cancer and mitochondrial function

Universidad Nacional de Colombia. Facultad de Medicina. Revista

Saavedra-Torres, Jhan Sebastian¹  Díaz-Córdoba, Wilmer Jair¹  Zúñiga-Cerón, Luisa Fernanda²  Pinzón-Fernández, María Virginia²  Freyre-Bernal, Sofía Isabel² 

[1] Corporación Del Laboratorio al Campo, Popayán, Colombia;Universidad del Cauca, Popayán, Colombia

关键词: Cancer;    Glycolysis;    Mitochondria;    Neovascularization pathologic (MeSH).;   

DOI  :  10.15446/revfacmed.v66n1.59898

学科分类：医学（综合）

来源: Universidad Nacional de Colombia * Facultad de Medicina

【 摘 要 】

Metabolism alterations are associated with the loss of mitochondrial function in tumor cells. Current research discuss whether such loss is evident in function itself, or if cells can provide maximum stability to its functions. More studies are needed to determine the behavior of cancer in mitochondria. Tumor cells experience a limitation of oxygen and mutations in oncogenes, tumor suppressor genes and enzymes of the glycolytic pathway and/or mitochondrial oxidative metabolism, thus allowing the formation of aggressive cancer. This article is the result of a literature review of the scientific evidence that has been presented in the latest research on cancer and mitochondrial function.

【 授权许可】

CC BY