Investigating The Role of Novel Bioactive Compound from Ficus Virens Ait on Cigarette Smoke Induced Oxidative Stress and Hyperlipidemia in Rats

Iranian Journal of Pharmaceutical Research

关键词: Cigarette smoke;    Oxidative stress;    Hyperlipidemia;    Ficus virens;    bioactive compound;   

DOI  :  

学科分类：社会科学、人文和艺术（综合）

来源: Shaheed Beheshti Medical University * School of Pharmacy

【 摘 要 】

The present study is premeditated to extenuate the role of Ficus virens extract and itsbioactive compound on cigarette smoke, an important risk factor for CVD, induced oxidativestress and hyperlipidemia. Cigarette smoke (CS) exposure to rats results in significant loss ofbody weight and increases blood carbon monoxide saturation (carboxyhemoglobin), nicotine,plasma TC, TG, and LDL-C levels but reduced level of antiatherogenic HDL-C. Moreover,owing to substantial oxidative stress generated in rats due to cigarette smoke a significantincrease in plasma and erythrocytes lipid peroxidation products were observed which was wellcorrelated with increase in ex-vivo BDC (48%) and MDA (53%) level (p < 0.001). Simultaneousadministration of FVBM extract at higher dose (100 mg/rat) and F18 (n-Octadecanyl-O-α-Dglucopyranosyl(6’→1’’)-O-α-D-glucopyranoside) compound to CS-exposed rats effectivelyblocked the increase in plasma lipid and lipoprotein levels (p < 0.001) which was due to themarked suppression in the hepatic HMG-CoA reductase activity (p < 0.001) and significantlyinhibit the lipid peroxidation process thus preventing the membrane damage, LDL oxidation,and in turn subsequent atherosclerosis. Thus, the results clearly demonstrated the protectiverole of FVBM extract and F18 compound in risk factor induced cardiovascular disease.

【 授权许可】

CC BY