Amphotericin B: an antifungal drug in nanoformulations for the treatment of paracoccidioidomycosis

Universidad Industrial de Santander. Revista. Salud

Pereira Garcia, Mônica¹  Arruda Saldanha, Camila¹  Bentes Azevedo, Ricardo¹  Menezes Almeida Santos, Maria de Fátima¹  Cesar Iocca, Diêgo¹ 

[1] University of Brasília, Brasília, DF, Brazil

关键词: Paracoccidioides brasiliensis;    amphotericin B;    magnetite nanoparticles;    magnetic fluid;    drug delivery complex.;   

DOI  :  

学科分类：医学（综合）

来源: Universidad Industrial de Santander

【 摘 要 】

The use of magnetic nanoparticles (MNPs) in drug delivery vehicles must address issues such as drugloading capacity, desired release profile, aqueous dispersion stability, biocompatibility with cells and tissue, and retention of magnetic properties after interaction with macromolecules or modification via chemical reactions. Amphotericin B (AmB) is still the first choice for the treatment of severe paracoccidioidomycosis, an important systemic fungal infection caused by Paracoccidoides brasiliensis. Unfortunately, AmB causes acute side effects (mainly urinary problems) following intravenous administration, which limits its clinical use. The use of magnetic nanoparticles stabilized with biocompatible substances, together with the possibility of their conjugation with drugs has become a new nanotechnological strategy in the treatment of diseases for drug delivery to specific locations, such as the lungs in paracoccidoidiodomycosis. This review provides an overview of the disease, its etiologic agent and treatment with emphasis on the main strategies to improve the use of AmB in nanoformulations.

【 授权许可】

Unknown