Technetium-99m tricarbonyl labeled a broad-spectrum quinolone as a specific imaging agent in infection diseases

Iranian Journal of Pharmaceutical Research

关键词: Infection;    99mTc-carbonyl;    Gemifloxacin;    Quinolone;    Imaging;   

DOI  :  

学科分类：社会科学、人文和艺术（综合）

来源: Shaheed Beheshti Medical University * School of Pharmacy

【 摘 要 】

Nuclear medicine imaging has been used to localize infection sites and efforts have been continued to develop modified infection specific radiopharmaceuticals. In this study gemifloxacin as a broad-spectrum quinolone has been labeled with [99mTc (CO)3 (H2O)3]+ core in order to evaluate its feasibility as an infection imaging agent for in vivo use. The stability of radioconjugate was checked in human serum at 37 °C and biodistribution was studied in mice. Labeling yield of >95% was obtained corresponding to a specific activity of 0.14 GBq/μmol. The radioconjugate showed good stability in human serum. Our main achievement was high accumulation in the infected muscle in mice (T/NT = 2.93 ± 0.3 at 1 h post injection) which may diagnostically be beneficial for differentiate sites of infection from sites of inflammation.

【 授权许可】

CC BY