Bioinformatic analysis of miRNAs targeting the key nuclear receptors regulating CYP3A4 gene expression: The challenge of the CYP3A4 “missing heritability” enigma

Journal of Applied Biomedicine

关键词: miRNA;    Gene regulation;    CYP3A4;    Cytochrome P450;    Metabolism;   

DOI  :  10.1016/j.jab.2015.04.002

学科分类：医学（综合）

来源: Elsevier

【 摘 要 】

The expression of the main cytochrome P450 enzyme CYP3A4 displays enormous interindividual variability. Studies addressing the genetic variability of either the CYP3A4 gene itself or its key transcription factors have not found any crucial polymorphism contributing to this variability in expression, a phenomenon is referred to as the “missing heritability of CYP3A4 variability.” Several reports have recently described microRNAs (miRNAs) targeting the CYP3A4 gene and/or its major transcription factors.

【 授权许可】

Unknown