Impact of patient- and intervention-related factors on the outcome of acute biliary pancreatitis treated by urgent ERCP and biliary sphincterotomy

International Journal of Medicine and Medical Sciences

Ferenc Lszl¹  Lajos Topa²  Jzsef Pozsr²  Pter Sahin²  Ildik Brandhuber³ 

[1] Department of Comparative Physiology, University of Szeged, Szeged, Hungary.;Department of Gastroenterology, Szent Imre Hospital, Budapest, Hungary.;Medical Faculty, Semmelweis University, Budapest, Hungary.

关键词: Acute biliary pancreatitis;    sphincterotomy;    risk- factors;    outcome.;   

学科分类：医学（综合）

来源: Academic Journals

【 摘 要 】

Risk factors of post- ERCP pancreatitis are well characterized in various clinical settings. These factors may worsen the outcome of acute biliary pancreatitis treated by endoscopic sphincterotomy. Our aim was to investigate the effect of patient- and intervention- related factors on the outcome of acute biliary pancreatitis treated by endoscopic sphincterotomy. The data of 69 retrospectively analyzed using multiple logistic regression method to explore factors significantly associated with the outcome of pancreatitis. We found that multi-system organ failure was associated with predicted severe pancreatitis (odds ratio [OR] 24.24; 95% confidence interval [CI]: 1.35 – 434.76; p = 0.030), condition of previous cholecystectomy (OR 23.94; 95% CI: 1.58 – 361.03; p = 0.022) and the performance of access precut sphincterotomy (OR 21.34; 95% CI: 1.32 – 344.92; p = 0.031). Predictors of development of necrosis were post-sphincterotomy bleeding (OR 52.01; 95% CI: 1.67 – 1617.54; p = 0.024), the predicted severe pancreatitis at admission (OR 20.30; 95% CI: 2.92 – 141.19; p = 0.002) and female gender (OR 6.70; 95% CI: 1.00 – 44.73; p = 0.049). The single variable post-cholecystectomy state proved to be a predictor of mortality (OR 13.40; 95% CI: 1.5-∞; p = 0.026). We concluded that the outcome of acute biliary pancreatitis treated by ERCP and biliary sphincterotomy of acute biliary pancreatitis is influenced by certain patient- and intervention-related factors.

【 授权许可】

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