Ameliorative effects of -tocopherol on cypermethrin induced oxidative stress and lipid peroxidation in Wistar rats

International Journal of Medicine and Medical Sciences

Rajinder Raina¹  Vinay Kant¹  Pawan Kumar Verma¹  N. K. Pankaj¹ 

[1] Division of Pharmacology and Toxicology, Faculty of Veterinary Sciences and Animal Husbandry, Sher-e-Kashmir University of Agricultural Sciences and Technology, R.S. Pura, Jammu-181102, J&K, India.

关键词: Cypermethrin;    oxidative stress;    α    -tocopherol;    Wistar rats.;   

学科分类：医学（综合）

来源: Academic Journals

【 摘 要 】

Environmental contamination of pyrethroids is responsible for increasing oxidative stress in man and animals. The present study was aimed to investigate the ameliorative effects of α-tocopherol on different stress parameters in rats. Significant (p<0.05) increased catalase activity in cypermethrin treated rats is maintained normal by the supplementation of α-tocopherol. Significantly reduced (p<0.05) SODs and GSH-Px activity by cypermethrin treated rats and activity of these enzymes were comparable to control animals by α-tocopherol supplementation. Significantly reduced GSH and increased (p<0.05) lipid peroxidation were observed in both groups, cypermethrin alone and along with the α-tocopherol treated groups. Observations from the present study suggest that α-tocopherol supplementation plays a protective role in cypermethrin induced oxidative stress in rats and linseed oil is not suitable as a vehicle for α-tocopherol.

【 授权许可】

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