Experimental chronic inflammation induced in mice periodontium by Actinomyces israelii entrapped in alginate gel

International Journal of Medicine and Medical Sciences

Vladimir Reimar A. Souza Noronha¹  Srgio Monteiro Lima Jr¹  Evandro Guimares Aguiar¹  Vagner Rodrigues Santos¹  Joo Luis Duval Cndido da Silva¹  Mariana Passos De Luca¹  Felipe Alcntara Braga¹  Mrcio M. Mattos² 

[1] Laboratory of Microbiology and Biomaterials, Facult of Dentistry, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.;Laboratory of Pharmacology, Facult of Pharmacy, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.

关键词: Actinomycis israelii;    chronic infection;    alginate gel;    experimental actinomycosis;    periodontium;    mice.;   

学科分类：医学（综合）

来源: Academic Journals

【 摘 要 】

Experimental chronic inflammation in periodontal actinomycosis was studied with INCQS standard Actinomyces israelii infected mandibula in Swiss/NIH mice (n = 45), male and female with 21 days of age. Tissue responses to experimentally induced chronic inflammation were investigated in mice by clinical and light microscopy. After anesthetization, the animals were innoculated in paraperiosteal periodontium anterior mandibula with 108 UFC/mL A. israelii (n = 45) associated with sodium alginate gel particles. The animals had been evaluated clinically and microscopicaly at 1, 3, 7, 15, 21, 30 and 45 days after innoculation. Chronic inflammation was induced in all the mice when compared to control animals. Both groups had normal general health throughout the study. In control mice (n = 10) no lesions were noted. The clinical and histopathology evolutions of actinomycosis lesions had been observed and are discuted in this work. 

【 授权许可】

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