Global fetal DNA methylation and birth outcomes in obese women

Proceedings in Obstetrics and Gynecology

Karla N. Solheim¹  Eric J. Devor¹  Donna A. Santillan¹  Mark K. Santillan¹  Sabrina Scroggins¹ 

[1] Department of Obstetrics and Gynecology, Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, 52242

关键词: DNA methylation;    obesity;    respiratory distress syndrome;    pregnancy;    diabetes;    maternal;    gestational;    fetal;   

学科分类：妇产科学

来源: University of Iowa

【 摘 要 】

Pregnant women who are obese are more likely to have gestational diabetes, gestational hypertension, pre-eclampsia, macrosomia, operative vaginal delivery, and cesarean delivery. Obesity also has adverse implications for the neonate. Congenital anomalies are more common in children born to obese women. These include neural tube defects, gastroschisis, cardiovascular anomalies, and others. Although the connection between maternal obesity and chronic health conditions has been described, the mechanism by which this occurs is less well understood. Changes to the epigenetic structure of offspring DNA have been proposed as one such mechanism.

【 授权许可】

Unknown