Anti-hyperglycaemic, lipid lowering and anti-oxidant properties of [6]-gingerol in db/db mice

International Journal of Medicine and Medical Sciences

Amar Bahadur Singh¹  Arvind Kumar Srivastava¹  Rakesh Maurya²  Akanksha²  Nilendra Singh³ 

[1] Biochemistry Division, Central Drug Research Institute, Lucknow-226001, India.;Medicinal and Process Chemistry Division, CDRI, Lucknow-226001, India.;Pharmacology Division CDRI, Lucknow-226001, India.

关键词: Antihyperglycaemic;    antioxidant;    antilipidemic;    reactive oxygen species;    db/db mice;    [6]-gingerol..;   

学科分类：医学（综合）

来源: Academic Journals

【 摘 要 】

In the present study, we investigated the blood glucose lowering, lipid lowering and antioxidant effect of [6]-gingerol in type 2 diabetic db/db mice. Treatment of db/db mice with [6]-gingerol (100 mg/kg bw) for 12 days significantly (p<0.05) lowered fasting blood glucose and improved the glucose tolerance in db/db mice. Oral administration of [6]-gingerol also significantly (p < 0.05) decreased plasma triglycerides (TG), total cholesterol (TC), free fatty acid (FFA), low-density lipoprotein cholesterol (LDL-C) and plasma insulin concentration. In addition, [6]-gingerol significantly (p < 0.05) reduces the content of hydrogen peroxide or suppresses the reactive oxygen species (ROS) generation and restores the enzyme activity of catalase (CAT), glutathione peroxidase (GPx) and superoxide dismutase (SOD) in db/db mice. These findings suggest that [6]-gingerol exhibits a significant potential as an anti-hyperglycaemic, lipid lowering and anti-oxidant agent for the treatment of type 2 diabetes.

【 授权许可】

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