Endomicroscopy with Fluorescent CD105 Antibodies for In Vivo Imaging of Colorectal Cancer Angiogenesis

Current Health Sciences Journal

Adriana Cioclteu ; D. PIRICI ; Claudia Valentina Georgescu ; V. Surlin ; A. Sftoiu

关键词: CD105-FITC;    colorectal cancer;    confocal laser endomicroscopy (CLE);    in vivo endoscopic imaging;    neoangiogenesis;   

学科分类：医学（综合）

来源: Universitatea de Medicina si Farmacie din Craiova / University of Medicine and Pharmacy

【 摘 要 】

The aim of this case report was to evaluate the feasibility of in vivo acquisition of microscopic images using fluorescent CD105 antibodies for molecular imaging in human colorectal cancer. After excluding the presence of tissue autofluorescence, the antibody solution was topically administered through a spray-catheter. The targeted area was analyzed by eCLE and images were recorded. The fractal dimension of tumor vessels and the vessel density were determined using ImageJ software. Immunohistochemistry was used as a gold standard. In vivo CLE analysis of CD105 expression enabled the study of tumor vascular network, revealing a chaotic structure.

【 授权许可】

Unknown