Elevated Levels of N-Terminal Pro-Brain Natriuretic Peptide in Patients with Chronic Dyspnea and Moderate Renal Dysfunction: Decreased Clearance or Increased Cardiac Stress

Cardiorenal medicine

Siegfried Wieshammer ; Jens Dreyhaupt ; Beate Basler

关键词: Cardiac stress;    Heart disease;    Natriuretic peptides;    Renal dysfunction;   

DOI  :  10.1159/000329537

学科分类：心脏病和心血管学

来源: S Karger AG

【 摘 要 】

Abstract Background/Aims: Serum levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) are often increased in patients with impaired renal function. The objective of this study was to investigate whether the increase in NT-proBNP is predominantly due to a reduced renal clearance or an increased cardiac secretion. Methods: A series of 697 outpatients (age: 57.5 8 16.4 years) referred for evaluation of dyspnea were assigned to 4 groups according to their estimated glomerular filtration rat.

【 授权许可】

CC BY