| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| Overview and potential unifying themes of the atypical chemokine receptor family | |
| 关键词: signaling; β; ‐; arrestin; G protein coupled receptor; trafficking; expression; | |
| DOI : 10.1189/jlb.2MR1015-477R | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
Chemokinesmodulateimmuneresponsesthroughtheirabilitytoorchestratethemigrationoftargetcells.Chemokinesdirectlyinducecellmigrationthroughadistinctsetof7transmembranedomainGprotein‐coupledreceptorsbutarealsorecognizedbyasmallsubfamilyofatypicalchemokinereceptors,characterizedbytheirinabilitytosupportchemotacticactivity.Atypicalchemokinereceptorsarenowemergingascrucialregulatorycomponentsofchemokinenetworksinawiderangeofphysiologicandpathologiccontexts.Althoughanewnomenclaturehasbeenapprovedrecentlytoreflecttheirfunctionaldistinctionfromtheirconventionalcounterparts,asystematicviewofthissubfamilyisstillmissing.Thisreviewdiscussestheirbiochemicalandimmunologicpropertiestoidentifypotentialunifyingthemesinthisemergingfamily...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201904048825067ZK.pdf | 760KB |  download |
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