At the Bedside: Helicobacter pylori, dysregulated host responses, DNA damage, and gastric cancer

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: gastric carcinogenesis;    eradication therapy;    chemoprevention;    intestinal metaplasia;    single nucleotide polymorphisms;   

DOI  :  10.1189/jlb.4BT0214-100R

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

ClinicaltrialsperformedinpopulationsathighGCriskhavedemonstratedthateradicationofHelicobacterpylorifromthestomachwithacourseofcombinationantimicrobialshelpspreventgastriccarcinogenesiswhentheyareadministeredbeforeprecancerouslesionshaveyetdeveloped.Inthisreview,weconsidertheinsightsintoH.pylori‐associatedgastriccarcinogenesisthathavebeengainedfromtheseandmanyotherclinicalstudiesinthefieldtohighlightpriorityareasforbasicresearchandclinicalinvestigation.AmongthesearedefiningthemagnitudeoftheriskreductionthatmaybeachievedinclinicalpracticeandatapopulationlevelbyH.pylorieradicationandinvestigatingwhen,duringtheslowmultistepprogressiontoGC,interventionwillbeofthemostbenefit.AdditionalstrategiestopreventGCinducedbyH.pylori,includingchemoprevention,dietarymodification,andcloseendoscopicsurveillance,mayalsohavevalueinaugmentingtheriskreduction.WhyonlyasmallsubpopulationofthoseinfectedbyH.pylorigoontodevelopGCmaybepartiallyexplainedbygeneticsusceptibilityrelatedtoSNPsinseveralgenesregulatingtheintensityofthegastricinflammatoryresponsetoH.pylori.InvestigationofthebasicmechanismsunderlyingthepromotionofGCbyH.pyloriandtheassociatedinflammatoryresponsewilllikelycontinuetoimproveclinicalstrategiesforthepreventionofoneofthemostcommoncausesofcancerdeathglobally.Seerelatedreview,AttheBench:H.pylori,dysregulatedhostresponses,DNAdamage,andgastriccancer...

【 授权许可】

CC BY