Salt Loading Promotes Kidney Injury via Fibrosis in Young Female Ren2 Rats

Cardiorenal medicine

Javad Habibi ; Melvin R. Hayden ; Carlos M. Ferrario ; James R. Sowers ; Adam T. Whaley-Connell

关键词: Angiotensin II;    Transgenic (mRen2)27 rat;    Proteinuria;    Fibrosis;    Reactive oxygen species;   

DOI  :  10.1159/000360866

学科分类：心脏病和心血管学

来源: S Karger AG

【 摘 要 】

Abstract Background/Aims: It is increasingly recognized that there is sexual dimorphism in kidney disease progression; however, this disparity is lost in the presence of diabetes where women progress at a similar rate to men. The renin-angiotensin-aldosterone system (RAAS) is known to regulate diabetes-induced kidney injury, and recent literature would suggest that gender differences exist in RAAS-dependent responses in the kidney. In this regard, these gender differences may be overcome by exce.

【 授权许可】

CC BY