Cross‐talk between intraepithelial γδ T cells and epithelial cells

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: lymphocytes;    epithelium;    wound repair;    dendritic epidermal T cells;   

DOI  :  10.1189/jlb.0213101

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

IntraepithelialγδTcellsplaypivotalrolesinhomeostasis,tissuerepair,inflammation,andprotectionfrommalignancy.Insometissues,γδTcellsaretheonlyresidentTcellpopulation,whereasinothers,theycoexistwithαβTcellsandotherlymphocytepopulations.γδTcellfunctionintheepitheliumrequiresconstantcommunicationbetweencellsintheformofcell‐to‐cellcontactsandcell‐to‐matrixinteractions.Theseinteractionscoordinatewiththetimelyproductionofspecificcytokines,chemokines,growthfactors,andglycosaminoglycans,whichhavespecializedeffectsonneighboringepithelialcells.AntigensthatactivatetheseTcellsarenotwell‐defined,andtheydonotexpressclassiccostimulatoryorcoreceptormolecules.Assuch,anunderstandingofthemechanismsusedbyepithelialγδTcellstomaintainhomeostasisandfacilitatewoundrepairhasnecessitatedtheidentificationofnovelmolecularinteractionsbetweenγδTcellsandtheirneighboringepithelialcells...

【 授权许可】

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