Innate immune processes are sufficient for driving silicosis in mice

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: lung;    inflammation;    fibrosis;    lymphocyte;    cytokine;    inflammasome;   

DOI  :  10.1189/jlb.0210108

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Thelungisconstantlyexposedtopotentiallypathogenicparticlesandmicroorganisms.Ithasbecomeevidentrecentlythatnotonlyinnatebutalsoadaptiveimmuneresponsestoparticulates,suchasSiO2enteringtherespiratorytract,arecomplexanddynamicevents.Althoughthecellularmechanismsandanatomicalconsequencesinvolvedinthedevelopmentofsilicosishavebeenstudiedextensively,theystillremainpoorlyunderstood.Basedontheircapacityforimmuneregulation,lymphocytesmayplayakeyroleintherespiratoryresponsetoenvironmentalchallengebySiO2.TheobjectiveofthisstudywastocharacterizetheimpactofSiO2exposureonrespiratoryimmuneprocesses,withparticularemphasisonevaluatingtheimportanceoflymphocytesinthemurinesilicosismodel.Therefore,lymphopenicmice,includingNK‐deficient,Rag1−/−,oracombination(Rag1−/−NK‐depleted),wereusedanddemonstratedthatSiO2‐inducedfibrosisandinflammationcanoccurindependentlyofT,B,NKT,andNKcells.StudiesinRag1−/−micesuggestfurtherthatlymphocytesmayparticipateintheregulationofSiO2‐inducedinflammationthroughmodulationoftheNalp3inflammasome.Thisobservationmayhaveclinicalrelevanceinthetreatmentofinflammatoryandfibroticlungdiseasesthatarerefractoryorrespondsuboptimallytocurrenttherapeutics...

【 授权许可】

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