The invariant NKT cell subset in anti‐viral defenses: a dark horse in anti‐influenza immunity?

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: CD1d;    viral immunology;    influenza virus;    glycolipids;    Toll‐;    like receptors;   

DOI  :  10.1189/jlb.0410191

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

iNKTcells,asmallsubsetofαβTCR+Tcells,arecapableofproducinglargeamountsofcytokinesuponactivationthroughtheirTCR.UnlikeconventionalTcellsthatexpresshighlydiverseTCRs,iNKTcellsexpressaglycolipid‐reactiveinvariantTCR‐αchainpairedwithalimitednumberofβchain(s).ThesecellsrecognizeglycolipidantigenswhenpresentedonCD1dmoleculesfoundonAPCorothercells.AlthoughtheimmunoregulatoryrolesofiNKTcellsinthecontextofautoimmunediseasearefairlywellcharacterized,severallinesofevidencehighlighttheimportanceofthiscelltypeinimmuneresponsesagainstmicrobialinsultscausedbybacterial,viral,andparasiticpathogens.RecentstudiesthathaveinvestigatedtheroleofiNKTcellsinimmuneresponsesagainstinfluenzavirushavesuggestedanimportantroleforthesecellsininnatedefensemechanismsaswellasantibody‐andcell‐mediatedresponses.ThisreviewhighlightstheimportantcontributionsofiNKTcellstoimmuneresponsesagainstviralpathogenswithparticularemphasisonimmunitytoinfluenzainfections...

【 授权许可】

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