| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| The immune theory of psychiatric diseases: a key role for activated microglia and circulating monocytes | |
| 关键词: schizophrenia; bipolar disorder; animal models; PET; NOD mouse; | |
| DOI : 10.1189/jlb.0212100 | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
Thisreviewdescribesakeyroleformononuclearphagocytesinthepathogenesisofmajorpsychiatricdisorders.Thereisaccumulatingevidenceforactivationofmicroglia(histopathologyandPETscans)andcirculatingmonocytes(enhancedgeneexpressionofimmunegenes,anoverproductionofmonocyte/macrophage‐relatedcytokines)inpatientswithbipolardisorder,majordepressivedisorder,andschizophrenia.Thesedataarestrengthenedbyobservationsinanimalmodels,suchastheMIAmodels,thechronicstressmodels,andtheNODmousemodel.Intheseanimalmodelsofdepressive‐,anxiety‐,andschizophrenia‐likebehavior,similaractivationsofmicrogliaandcirculatingmonocytescanbefound.Theseanimalmodelsalsomakein‐depthpathogenicstudiespossibleandshowthatmicrogliaactivationimpactsneuronaldevelopmentandfunctioninbrainareascongruentwiththealtereddepressiveandschizophrenia‐likebehaviors...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201904048309090ZK.pdf | 1796KB |  download |
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