Fas regulates neutrophil lifespan during viral and bacterial infection

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: apoptosis;    TLR;    IL‐;    18;    LCMV;    Citrobacter rodentium ;   

DOI  :  10.1189/jlb.3AB1113-594RR

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Theregulationofneutrophillifespaniscriticalforacircumscribedimmuneresponse.NeutrophilsaresensitivetoFas/CD95deathreceptorsignalinginvitro,butitisunknownifFasregulatesneutrophillifespaninvivo.WehypothesizedthatFasL‐expressingCD8+Tcells,whichkillantigen‐stimulatedTcellsduringchronicviralinfection,canalsoinduceneutrophildeathintissuesduringinfection.WiththeuseofLysM‐CreFasfl/flmice,whichlackFasexpressioninmacrophagesandneutrophils,weshowthatFasregulatesneutrophillifespanduringlymphocyticchoriomeningitisvirus(LCMV)infectioninthelung,peripheralblood,andspleen.FasalsocontributedtotheregulationofneutrophilnumbersinthecolonofCitrobacterrodentium‐infectedmice.ToexaminetheeffectsofinfectiononFasactivationinneutrophils,weprimedneutrophilswithTLRligandsorIL‐18,resultinginablationofFasdeathreceptorsignaling.ThesedataprovidethefirstinvivogeneticevidencethatneutrophillifespaniscontrolledbydeathreceptorsignalingandprovideamechanismtoaccountforneutrophilresistancetoFasstimulationduringinfection...

【 授权许可】

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