Frequencies of FoxP3+ naïve T cells are related to both viral load and naïve T cell proliferation responses in HIV disease

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: CD4+ ;    immune activation;    T regulatory cells;    AIDS;   

DOI  :  10.1189/jlb.1210661

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

HIVinfectionresultsindepletionanddysfunctionofnaïveCD4+Tcells.Themechanismsunderlyingthesedeficienciesarenotunderstood.WeinvestigatedthefrequenciesofCD4+naïvesubsetsinHIVdiseaseasdefinedbyexpressionofCD25and/orFoxP3andtherelationshipofthesefrequenciestonaïveTcellproliferationfunction.WeobservedincreasedproportionsofCD25+FoxP3+andCD25+FoxP3–cellsanddecreasedproportionsofCD25–FoxP3–cellswithinthenaïveCD4+cellcompartmentfromHIV‐infectedpersonscomparedwithfindingsinhealthydonors.TheseperturbationswererelatedtohigherplasmaHIVRNAlevelsbutnotwithhigherimmuneactivation,asmeasuredbytheproportionsofCD38+memoryCD4+Tcells.NaïveTcellproliferationresponsestomitogenstimulationwereinverselyrelatedtothefrequenciesandabsolutenumbersofFoxP3+naïveTcells.MDA,amarkerofoxidativestress,andsCD14,amarkerofmonocyteactivationandasurrogateformicrobialtranslocation,wereincreasedinserumsamplesfromHIV+donors;however,neithermarkerwasrelatedtonaïveTcellfunctioninHIV+donors.TheseobservationssuggestthatalterationsinnaïveTcellsubsetfrequenciescouldcontributetonaïveTcelldysfunctioninHIVdisease,butthesealterationsarenotnecessarilytheresultofchronicimmuneactivation...

【 授权许可】

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