Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
AIM/CD5L: a key protein in the control of immune homeostasis and inflammatory disease | |
关键词: Spα; macrophage; metabolic disease; SRCR domain; cancer; | |
DOI : 10.1189/jlb.3RU0215-074R | |
学科分类:生理学 | |
来源: Federation of American Societies for Experimental Biology | |
【 摘 要 】
CD5L,asolubleproteinbelongingtotheSRCRsuperfamily,isexpressedmostlybymacrophagesinlymphoidandinflamedtissues.TheexpressionofthisproteinistranscriptionallycontrolledbyLXRs,membersofthenuclearreceptorfamilythatplaymajorrolesinlipidhomeostasis.ResearchundertakenoverthelastdecadehasuncoveredcriticalrolesofCD5LasaPRRofbacterialandfungalcomponentsandinthecontrolofkeymechanismsininflammatoryresponses,withinvolvementinprocesses,suchasinfection,atherosclerosis,andcancer.Inthisreview,wesummarizethecurrentknowledgeofCD5L,itsrolesattheintersectionbetweenlipidhomeostasisandimmuneresponse,anditspotentialuseasadiagnosticbiomarkerinavarietyofdiseases,suchasTBandlivercirrhosis...
【 授权许可】
CC BY
【 预 览 】
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