Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
NKG2D ligand overexpression in lupus nephritis correlates with increased NK cell activity and differentiation in kidneys but not in the periphery | |
关键词: MICA; Rae; MRL/MpJ; MRL/lpr; T‐; bet; Eomes; | |
DOI : 10.1189/jlb.4A0714-326R | |
学科分类:生理学 | |
来源: Federation of American Societies for Experimental Biology | |
【 摘 要 】
NKcellsareamajorcomponentoftheimmunesystem,andalterationsintheiractivityarecorrelatedwithvariousautoimmunediseases.Inthepresentwork,weobservedanincreasedexpressionoftheNKG2DligandMICAinSLEpatients’kidneysbutnothealthysubjects.Wealsoshowglomerulus‐specificexpressionoftheNKG2DligandsRae‐1andMult‐1invariousmurineSLEmodels,whichcorrelatedwithahighernumberofglomerular‐infiltratingNKcells.AstheroleofNKcellsintheimmunopathogenesisofSLEispoorlyunderstood,weexploredNKcelldifferentiationandactivityintissuesandorgansinSLE‐pronemurinemodelsbyuseofdiseasedandprediseasedMRL/MpJandMRL/lprmice.WereportherethatphenotypicallyiNKcellsaccumulateonlyinthespleenbutnotinBMorkidneysofdiseasedmice.InfiltratingNKcellsinkidneysundergoingalupusnephriticprocessshowedamoremature,activatedphenotypecomparedwithkidney,aswellasperipheralNKcellsfromprediseasedmice,asdeterminedbyIFN‐γandSTAT5analysis.Thesefindingsandthepresenceofglomerulus‐specificNKG2Dligandsinlupus‐pronemiceidentifyaroleforNKcellsandNKG2Dligandsinthelupusnephriticprocess,whichcouldaidinunderstandingtheirroleinhumanSLE...
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