期刊论文详细信息
Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society
NKG2D ligand overexpression in lupus nephritis correlates with increased NK cell activity and differentiation in kidneys but not in the periphery
关键词: MICA;    Rae;    MRL/MpJ;    MRL/lpr;    T‐;    bet;    Eomes;   
DOI  :  10.1189/jlb.4A0714-326R
学科分类:生理学
来源: Federation of American Societies for Experimental Biology
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【 摘 要 】

NKcellsareamajorcomponentoftheimmunesystem,andalterationsintheiractivityarecorrelatedwithvariousautoimmunediseases.Inthepresentwork,weobservedanincreasedexpressionoftheNKG2DligandMICAinSLEpatients’kidneysbutnothealthysubjects.Wealsoshowglomerulus‐specificexpressionoftheNKG2DligandsRae‐1andMult‐1invariousmurineSLEmodels,whichcorrelatedwithahighernumberofglomerular‐infiltratingNKcells.AstheroleofNKcellsintheimmunopathogenesisofSLEispoorlyunderstood,weexploredNKcelldifferentiationandactivityintissuesandorgansinSLE‐pronemurinemodelsbyuseofdiseasedandprediseasedMRL/MpJandMRL/lprmice.WereportherethatphenotypicallyiNKcellsaccumulateonlyinthespleenbutnotinBMorkidneysofdiseasedmice.InfiltratingNKcellsinkidneysundergoingalupusnephriticprocessshowedamoremature,activatedphenotypecomparedwithkidney,aswellasperipheralNKcellsfromprediseasedmice,asdeterminedbyIFN‐γandSTAT5analysis.Thesefindingsandthepresenceofglomerulus‐specificNKG2Dligandsinlupus‐pronemiceidentifyaroleforNKcellsandNKG2Dligandsinthelupusnephriticprocess,whichcouldaidinunderstandingtheirroleinhumanSLE...

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