Candida albicans escapes from mouse neutrophils

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: killing;    immune evasion;    myeloperoxidase;    defensins;   

DOI  :  10.1189/jlb.0213063

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Candidaalbicans,themostcommonlyisolatedhumanfungalpathogen,isabletogrowasbuddingyeastsorfilamentousforms,suchashyphae.TheabilitytoswitchmorphologyhasbeenattributedacrucialroleforthepathogenesisofC.albicans.Tomimicdisseminatedcandidiasisinhumans,themouseisthemostwidelyusedmodelorganism.Neutrophilsareessentialimmunecellstopreventopportunisticmycoses.Toexplorepotentialdifferencesbetweentherodentinfectionmodelandthehumanhost,wecomparedtheinteractionsofC.albicanswithneutrophilgranulocytesfrommiceandhumans.WerevealedthatmurineneutrophilsexhibitedasignificantlylowerabilitytokillC.albicansthantheirhumancounterparts.Strikingly,C.albicansyeastcellsformedgermtubesuponinternalizationbymurineneutrophils,eventuallyrupturingtheneutrophilmembraneandthereby,killingthephagocyte.Onthecontrary,growthandsubsequentescapeofC.albicansareblockedinsidehumanneutrophils.Accordingtoourfindings,thisblockageinhumanneutrophilsmightbearesultofhigherlevelsofMPOactivityandthepresenceofα‐defensins.Wethereforeoutlinedifferencesinantifungalimmunedefensebetweenhumansandmousestrains,whichfacilitatesamoreaccurateinterpretationofinvivoresults...

【 授权许可】

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