Molecular mechanisms of Ebola pathogenesis

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: viral hemorrhagic fever;    immunoevasion;    antivirals;    Ebola vaccines;    Ebola survivors;   

DOI  :  10.1189/jlb.4RI0316-099RR

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Ebolaviruses(EBOVs)andMarburgviruses(MARVs)areamongthedeadliesthumanviruses,ashighlightedbytherecentandwidespreadEbolavirusoutbreakinWestAfrica,whichwasthelargestandlongestepidemicofEbolavirusdisease(EVD)inhistory,resultinginsignificantlossoflifeanddisruptionsacrossmultiplecontinents.Althoughthenumberofcaseshasnearlyreacheditsnadir,arecentclusterof5casesinGuineaonMarch17,2016,hasextendedtheenhancedsurveillanceperiodtoJune15,2016.New,enhanced90‐dsurveillancewindowsreplacedthe42‐dsurveillancewindowtoensuretherapiddetectionofnewcasesthatmayarisefromamissedtransmissionchain,reintroductionfromananimalreservoir,ormoreimportant,reemergenceofthevirusthathaspersistedinanEVDsurvivor.Inthisreview,wesummarizeourcurrentunderstandingofEBOVpathogenesis,describevaccineandtherapeuticcandidatesinclinicaltrials,anddiscussmechanismsofviralpersistenceandlong‐termhealthsequelaeforEVDsurvivors...

【 授权许可】

CC BY