| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| microRNAs function in CD8+T cell biology | |
| 关键词: development; activation; differentiation; | |
| DOI : 10.1189/jlb.1RU0814-369R | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
Duringanimmuneresponse,CD8+Tcellscandifferentiateintomultipletypesofeffectorandmemorycellsthatareimportantcomponentsofimmunesurveillance.However,theirdysregulationhasbeenimplicatedininfectionwithvirusesorintracellularbacteriaandtumorigenesis.miRNAshavebeenidentifiedascrucialregulatorsofgeneexpression,andtheyperformthisfunctionbyrepressingspecifictargetgenesatthepost‐transcriptionallevel.MostmiRNAsexpressedinagivencelltypeservethefunctiontoimpedebroadlycell‐type‐inappropriategeneexpressionandpotentlydeepenapre‐existingdifferentiationprogram.ItisincreasinglyrecognizedthatmiRNAsdirectlymodulatetheconcentrationofmanyregulatoryproteinsthatarerequiredforthedevelopmentofimmunecellsinthethymusandtheirresponsesintheperiphery.ThisreviewoutlinesourcurrentunderstandingofthefunctionofmiRNAsinCD8+Tcellbiologyasitimpactsexpressionofprotein‐codinggenesinthecontextofproperdevelopment,infection,aswellasoncogenesis.Inaddition,weconcludewithaperspectiveonfuturechallengesandtheclinicalrelevanceofmiRNAbiology...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201904047465923ZK.pdf | 832KB |  download |
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