| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| Antigen specificity of immune suppression by myeloid‐derived suppressor cells | |
| 关键词: lymphocyte activation; tolerance; anergy; | |
| DOI : 10.1189/jlb.0111021 | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
Amongthemechanismssetinmotionbythetumortoescapethecontroloftheimmunesystem,MDSCsplayacentralroleininducingtolerancetoavarietyofanti‐tumoreffectors,includingTlymphocytes.IthasbeendemonstratedthatMDSCsexpandintumor‐bearingmiceandincancerpatients,leadingtoanimpairmentofTcellreactivityagainstthetumor.However,asthepresenceofMDSCsisnotcorrelatedwithageneralimmunesuppression,itwasadvancedthatamechanismregulatingthespecificityofMDSCinhibitionmustbepresent.Inthisarticle,wereviewtheliteratureshowingthatMDSCsexerttheirimmune‐suppressivefunctiononAg‐specificTcellresponsesbutattimes,alsoonmitogen‐activatedTlymphocytes,thereforebypassingtheAgdependency.WeproposethatthefeaturesofMDSC‐mediatedimmunesuppressionmightbeinfluencednotonlybythespecificmicroenvironmentinwhichMDSCsexpandandbythetumorcharacteristicsbutalsobythelevelsofactivationofthetargetlymphocytes...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201904046802836ZK.pdf | 137KB |  download |
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