Myeloid‐derived suppressor cells help protective immunity to Leishmania major infection despite suppressed T cell responses

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: ATRA;    MDSCs;    monocytes;    nitric oxide;    parasites;    suppression;   

DOI  :  10.1189/jlb.1110608

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Th1/Th2cytokinesplayakeyroleinimmuneresponsestoLeishmaniamajorbycontrollingmacrophageactivationforNOproductionandparasitekilling.MDSCs,includingmyeloidprecursorsandimmaturemonocytes,produceNOandsuppressTcellresponsesintumorimmunity.WehypothesizedthatNO‐producingMDSCscouldhelpimmunitytoL.majorinfection.Gr1hi(Ly6Chi)CD11bhiMDSCselicitedbyL.majorinfectionsuppressedpolyclonalandantigen‐specificTcellproliferation.Moreover,L.major‐inducedMDSCskilledintracellularparasitesinaNO‐dependentmannerandreducedparasiteburdeninvivo.Bycontrast,treatmentwithATRA,whichinducesMDSCstodifferentiateintomacrophages,increaseddevelopmentoflesions,parasiteload,andTcellproliferationindrainingLNs.Altogether,theseresultsindicatethatNO‐producingMDSCshelpprotectiveimmunitytoL.majorinfection,despitesuppressedTcellproliferation...

【 授权许可】

CC BY