High-NaCl Diet Aggravates Cardiac Injury in Rats with Adenine-Induced Chronic Renal Failure and Increases Serum Troponin T Levels

Cardiorenal medicine

Pavlos Kashioulis ; Ola Hammarsten ; Niels Marcussen ; Emman Shubbar ; Aso Saeed ; Gregor Guron

关键词: Chronic renal failure;    Adenine;    Hypertension;    Left ventricular hypertrophy;    Troponin T;    High-sodium diet;   

DOI  :  10.1159/000446547

学科分类：心脏病和心血管学

来源: S Karger AG

【 摘 要 】

Abstract Aims: To examine the effects of 2 weeks of high-NaCl diet on left ventricular (LV) morphology and serum levels of cardiac troponin T (cTnT) in rats with adenine-induced chronic renal failure (ACRF). Methods: Male Sprague-Dawley rats either received chow containing adenine or were pair-fed an identical diet without adenine [controls (C)]. Approximately 10 weeks after the beginning of the study, the rats were randomized to either remain on a normal NaCl diet (NNa; 0.6%) or to be switched .

【 授权许可】

CC BY