Extracellular traps and macrophages: new roles for the versatile phagocyte

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: METs;    ETosis;    DNA;    antimicrobial mechanisms;    innate immunity;   

DOI  :  10.1189/jlb.4RI1014-521R

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

MΦaremultipurposephagocyteswithalargerepertoireofwell‐characterizedabilitiesandfunctions,includingregulationofinflammation,woundhealing,maintenanceoftissuehomeostasis,aswellasservingasanintegralcomponentoftheinnate‐immunedefenseagainstmicrobialpathogens.Workingalongwithneutrophilsanddendriticcells,theothermyeloid‐derivedprofessionalphagocytes,MΦareoneofthekeyeffectorcellsinitiatinganddirectingthehostreactiontopathogenicorganismsandresolvingsubsequentresponsesoncethethreathasbeencleared.ETsarearelativelynovelstrategyofhostdefenseinvolvingexpulsionofnuclearmaterialandembeddedproteinsfromimmunecellstoimmobilizeandkillbacteria,fungi,andviruses.AsresearchonETsexpands,ithasbeguntoencompassmanyimmunecelltypesinunexpectedways,includingvarioustypesofMΦ,whicharenotonlycapableofgeneratingMETsinresponsetovariousstimuli,butrecentpreclinicaldatasuggestthattheyareanimportantagentinclearingETsandlimitingET‐mediatedinflammationandtissuedamage.ThisreviewaimstosummarizehistoricalandrecentfindingsofbiologicresearchregardingETformationandfunctionanddiscusstheroleofMΦinETphysiologyandassociatedpathologies...

【 授权许可】

CC BY