β2‐Integrins in demyelinating disease: not adhering to the paradigm

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: adhesion molecules;    neuroimmunology;    experimental autoimmune encephalomyelitis;    multiple sclerosis;    T cells;   

DOI  :  10.1189/jlb.1009654

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Theβ2‐integrinsareasubfamilyofintegrinsexpressedonleukocytesthatplayanessentialroleinleukocytetrafficking,activation,andmanyotherfunctions.StudiesinEAE,theanimalmodelformultiplesclerosis,showdifferentialrequirementsforβ2‐integrinsinthisdiseasemodel,rangingfromcriticalinthecaseofLFA‐1(CD11a/CD18)tounimportantinthecaseofCD11d/CD18.Importantly,expressionofβ2‐integrinsonTcellsubsetsprovidessomecluesastothefunction(s)theseadhesionmoleculesplayindiseasedevelopment.Forexample,transferredEAEstudieshaveshownthatMac‐1(CD11b/CD18)expressiononαβTcellsiscriticalfordiseasedevelopment,andtheabsenceofLFA‐1onTregsinrecipientmiceresultsinexacerbateddisease.Inthisreview,wesummarizerecentfindingsregardingtheroleofβ2‐integrinsindemyelinatingdiseaseandnewinformationabouttheroleofβ2‐integrinswithrespecttoalterationsinTregnumbersandfunction.Inaddition,wediscussthepotentialfortargetingβ2‐integrinsinhumandemyelinatingdiseaseinlightoftherecentanimalmodelstudies...

【 授权许可】

CC BY