Determining the role of mononuclear phagocytes in prion neuroinvasion from the skin

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: transmissible spongiform encephalopathy;    Langerhans cells;    dendritic cells;    neutrophils;    follicular dendritic cell;    PrP;   

DOI  :  10.1189/jlb.1211633

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Manypriondiseasesareacquiredbyperipheralexposure,andskinlesionsareaneffectiverouteoftransmission.Followingexposure,earlyprionreplication,uponFDCsinthedrainingLNisobligatoryforthespreadofdiseasetothebrain.However,themechanismbywhichprionsareconveyedtothedrainingLNisuncertain.Here,transgenicmicewereused,inwhichlangerin+cells,includingepidermalLCsandlangerin+classicalDCs,werespecificallydepleted.Thesewereusedinparallelwithtransgenicmice,inwhichnonepidermalCD11c+cellswerespecificallydepleted.Ourdatashowthatprionpathogenesis,followingexposureviaskinscarification,occurredindependentlyofLCandotherlangerin+cells.However,thedepletionofnonepidermalCD11c+cellsimpairedtheearlyaccumulationofprionsinthedrainingLN,implyingaroleforthesecellsinthepropagationofprionsfromtheskin.Therefore,together,thesedatasuggestthatthepropagationofprionsfromtheskintothedrainingLNoccursviadermalclassicalDCs,independentlyoflangerin+cells...

【 授权许可】

CC BY