Induction of the human cathelicidin LL‐37 as a novel treatment against bacterial infections

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: innate immunity;    butyrate/phenylbutyrate;    vitamin D3 ;    antimicrobial peptides;   

DOI  :  10.1189/jlb.0412178

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Astraditionalantibioticsgraduallybecomeinefficient,thereisahighdemandfordevelopmentofanti‐infectiveswithamechanismofactionthatisdifferentfromexistingantibiotics.Currentantibioticstargetthepathogendirectly,therebycontributingtotheselectionofmultidrug‐resistantbacterialstrains.AMPs,suchasthehumancathelicidinLL‐37,aresmallcationicpeptidesthatarepartofhostdefense.Theyeliminatemicrobesthroughdiversemechanisms,therebycontributingtoresolutionofinfectionsandmaintenanceofepithelialbarrierfunction.Themultiplicityofthesemechanismsofactionmightbeakeytorestrictthedevelopmentofresistantbacterialstrains.ThediscoveryofLL‐37‐inducingcomponents,suchasbutyrateandvitaminD3,hasopenednewavenuestopreventortreatinfections.ButyrateandvitaminD3arepotentinducersofLL‐37butinaddition,havemanyothereffectsonhostimmunity.Here,wesummarizecurrentdataontheeffectsthatLL‐37anditsinducersdisplayontheinnateimmuneresponseanddiscussthefeasibilityfordevelopmentoftheseinducersaspossibledrugstopreventortreatinfections...

【 授权许可】

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